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FIGURE 2 Targeting various RCD pathways to treat cancer has been under intensive investigation for several decades (Peng et al., 2022)

Interestingly, of the combined phospho-sites identified by us and others, S155, T189, T230, S246 and S284 are known phosphorylation sites in mammalian ArfGAP1 according to the PhosphoSitePlus database, whereas intriguingly T291 rather than T292 is also a known phosphorylation site

3926-C INOSITOL-REQUIRING ENZYME 1a/X-BOX BINDING PROTEIN 1 (IRE1a/XBP1) PATHWAY REGULATES HEPATIC BILE ACID METABOLISM Mahmoud Khalafalla 1 , Andrew Benintende 2 , Xiaoying Liu 2 , Alyssa Kriegermeier 3 , Brian LeCuyer 2 and Richard M