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First, although copper is essential for autophagy, high concentrations of copper might induce mitophagy by generating mtROS [151,152,153], altering mitochondrial membrane potential or inhibiting mTOR activity [154, 155]

[DOI] [PubMed] [Google Scholar] 1266.Tauskela JS, Brunette E, OReilly N, Mealing G, Comas T, Gendron TF, Monette R, Morley P

Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, et al

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Additionally, studies investigating the relevance between MT expression and pathological/malignant conditions are severely limited in the prostate, and the regulatory mechanisms of zinc on MTs expression in prostate cells remain unclear