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This dual role may be attributable to the heterogeneity and plasticity of cancer-associated fibroblastsCAFs), largely dependent on their origin

In addition, a phase II trial demonstrated the efficacy of sorafenib in combination with docetaxel and cisplatin for the treatment of advanced GC, with an mOS of 13.6 months (114) and the most common grade 3/4 adverse reactions being neutropenia

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10.1016/j.msec.2014.01.012 202 ZhanJ.CuiY.ZhangP.DuY.HeckerP.ZhouS.et al (2025)