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Cell viability was assessed using CellTiter-Glo Luminescent Cell Viability Assay (Promega) per manufacturer instructions on a CLARIOstar Plate Reader (BMG Labtech)

However, in the presence of excess iron within the cell, H 2 O 2 triggers the Fenton reaction under the catalysis of ferrous iron (Fe 2+ ), leading to the production of -OH (Shi et al., 2023)

This has been demonstrated in a variety of cancer cell lines, tumor xenografts, spontaneous mouse tumors in transgenic animals and human tumor samples (references in Table 1 )

However, a more detailed understanding of the expression profile and reliance of these transporters is required

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