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Previously, a conspicuous relationship was observed between purine and monoamine metabolite concentrations in cerebrospinal fluid (CSF) during depressive illness suggesting the presence of a parallel purinergic and monoaminergic activation in the brain (Niklasson et al., 1983)

Br J Clin Pharmacol 81(3):428436 Edwards ET, Edwards ES, Davis E, Mulcare M, Wiklund M, Kelley G (2015) Comparative usability study of a novel auto-injector and an intranasal system for naloxone delivery

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**Promotion of Skin Health:** Glutathiones role in supporting the immune system and cellular function can indirectly contribute to overall skin health