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10.3390/molecules27062007 164 RathiA.RameshS

The thiopurine nucleosides that are formed are transported out of the cell, and thus, the natural function of NT5C2 is to regulate intracellular levels of purine monophosphates, but in the context of thiopurine therapy, it also reduces the amount of 6-TGN available for DNA incorporation (Fig

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

The ability to form these alternative secondary metabolites may be of considerable physiological importance in species, like the trout, that are unable to produce AFB 1 -GSH conjugates

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