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Lactate accumulation is commonly accepted as a sign of mitochondrial ill-health, indicating that mitochondria are not able to utilize either glucose or lactate as the source of energy [24]

149,150 In turn, insulin also plays a role in leptin production stimulation and secretion in adipose tissues

According to the National Institute of Health, depression (also known as major depression, major depressive disorder, or clinical depression) is a common but serious mood disorder which can cause severe symptoms that affect how a person feels, thinks, and handles daily activities, such as sleeping, eating, or working

The adrenal medulla, an extension of the sympathetic nervous system, on the other hand, produces catecholamines such as epinephrine (adrenaline) and norepinephrine (14) ( Figure 1 ), which have widespread impacts on the cardiovascular system, metabolism, and other body systems