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REDEFINE and SURMOUNT enrolled different cohorts (including with-diabetes vs without-diabetes arms), and diabetes status alone shifts expected weight loss

That works until it doesn't and the confounding variable of behavioral change makes clean research data nearly impossible

Both claim to help people lose body fat, but they could not be more different in how they work, what the science says, and what you should realistically expect

Nicotinamide Preservation 5-Amino-1MQ functions as a NAM-site competitive inhibitor, binding at the active site of NNMT and preventing the enzyme from methylating nicotinamide

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