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[16] [17] Intracellular signaling mechanisms [edit] When the growth hormone secretagogue receptor is activated, a variety of different intracellular signaling cascades can result, depending on the cell type in which the receptor is expressed

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10.1172/JCI105048 107

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567,568 CD14 + monocytes isolated from the blood of RA patients and individuals at risk have shown higher levels of glycolytic enzymes, including HIF-1, HK2, and PFKFB3, than those from healthy individuals

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This adaptive response may be caused by mutations that deactivate or activate tumor suppressor genes or oncogenes under hypoxic conditions

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