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While these studies highlight the neuroprotective potential of CQDs in controlled assays, HEWL is a model protein with limited structural homology to disease-relevant aggregates, and the in vitro assays do not fully reflect neuronal environments

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Higher amounts were not better: across trials, 1 mg and 2 mg three times daily and the 1/4/8 mg doses used in gluten-challenge studies did not outperform 0.5 mg, an atypical pattern researchers attribute to a surface-acting agent whose luminal effect may be self-limiting at higher concentrations [2] [5]

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To control for multiple comparisons, a false discovery rate (FDR) analysis was performed using the adaptive linear step-up procedures with Q set to 5 on all 112 P -values from both the linear (Figs