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By contrast, during oxidative stress, Nrf2 dissociates from Keap1, translocates to the nucleus, forms a heterodimer with small musculoaponeurotic fibrosarcoma oncogene homolog proteins and binds to ARE, thereby enhancing the transcription of antioxidant genes (6365)

Prevention of neural tube defects

From an expert perspective, this represents a paradigm of translational medicine, where insights from one neurological domain can illuminate potential pathways in another, potentially accelerating therapeutic discovery

PLoS ONE 17(3):e0265886

and celecoxib was demonstrated to alleviate ulcerative colitis in mice by inhibiting ferroptosis, suggesting it might also have the potential to modulate the ferroptosis process in OA (Li et al., 2024)