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The RNA-seq data are available in the Sequence Read Archive (PRJNA988963)

Faster turnover requires balance

Another study observed improvements in fertility outcomes and inhibition of endometriosis progression, with NAC reducing the size of endometrial cysts, lesion volume, and number

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Mechanistic studies indicate that RhoA exacerbates vascular permeability in OA by inhibiting endothelial cell adhesion proteins and actin filaments and by promoting endothelial ferroptosis ( 3.4 Glucose and energy metabolic pathways 3.4.1 Adaptive changes in glycolysis and oxidative phosphorylation in OA chondrocytes Under normal conditions, chondrocytes primarily derive energy through anaerobic glycolysis