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In AP models, excessive activation of DRP1 and/or downregulation of MFN1/2 and OPA1 has been associated with pathological mitochondrial fragmentation, loss of m, decreased ATP production, and accumulation of dysfunctional mitochondria (35, 38)

Then, 100 L of fresh FBS-free medium containing the extract treatment and 25 M DCFH-DA were added to each well, followed by incubation for 2 h at 37C

Further comprehensive research focusing on untouched areas of GBA may provide a better management strategy for PD and significantly improve patients quality of life