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Such higher alcohols are typically formed via the Ehrlich pathway, in which yeast metabolizes amino acids to produce fusel alcohols during fermentation

It does so by using a cofactor called methylcobalamin, a form of vitamin B12

A deficiency in the coenzyme can result in a disorder related to one caused by deficiency of the enzyme using that coenzyme

This usually involves signal transduction cascades, often leading to the activation of transcription factors that alter the expression of response genes to re-establish homeostasis