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However, addition of Fe resulted in 31% and 22% decrease of SOD activity in S-3/pKLH32 and S-3/pKLH337, respectively

PMC 3561070

In mouse studies, spermidine treatment resulted in decreased IL-17 levels in the corneas and lacrimal glands, stabilizing the tear film and mitigating ocular surface inflammation ( 4.5.4 Possible side effects and potential health risks While spermidine offers therapeutic benefits, its use in treating ocular conditions must be approached with caution due to potential cytotoxic effects