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Increased extracellular fluid is also seen in kidney failure when the body is not able to effectively get rid of water, or in heart failure when a weak heart is not able to pump or circulate blood effectively

Apoptosis It has been reported that a low concentration (8 M) of cisplatin causes renal tubular epithelial apoptosis, while a high concentration (800 M) of cisplatin induces necrosis [33]