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To further verify if the effects of H 2 O 2 treatment on mitochondrial proteostasis and mitophagy were indeed mediated through cysteine deprivation and CLPXP complex inactivation, the three cancer cell lines were treated simultaneously with both H 2 O 2 and cysteine (H 2 O 2 +Cys) or H 2 O 2 , ZK53 and CLPP overexpression (H 2 O 2 + ZK53 + CLPP OE)

An overview of the ferroptosis hallmarks in Friedreichs ataxia

Nat Immunol (2017) 18:133241

Most critically, patients with active malignancies or significant cancer risk factors may not be appropriate candidates due to the potential for promoting tumor growth and metastasis through angiogenesis stimulation