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The 5-amino-1-methylquinolinium structure carries a positive charge

(Best for absorption issues or severe deficiency) Treatment is usually safe and effective most symptoms resolve within weeks of starting therapy

Maralixibat (MRX), an ileal bile acid transporter inhibitor, was the first drug approved by the FDA for treatment of cholestatic pruritus in Alagille syndrome and is now approved for similar use in Progressive familial intrahepatic cholestasis