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As mitochondria produce energy, they naturally generate free radicals as a byproduct of metabolism

10.1016/j.yjmcc.2024.06.001 103 MarszalekP

In the liver, ALKBH5-mediated demethylation of TIR domain-containing adaptor protein (TIRAP) mRNA activates NF-B and c-Jun N-terminal Kinase/Mothers Against Decapentaplegic Homolog 2 (JNK/Smad2) signaling, thereby promoting radiation-induced hepatic fibrosis

Rather than destroying blood vessels, researchers could potentially develop drugs that interfere with fatty acid uptake into fat tissue, reducing fat accumulation without the dramatic tissue destruction