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Glutathione competitively inhibits melanin synthesis by interrupting L-DOPAs ability to bind with tyrosinase during melanin synthesis

In patients with TD at baseline randomized to receive SGAs in one large-scale trial, 76% met the criteria for TD at some or all subsequent visits, 24% did not meet the criteria at any visit, 32% showed more than 50% improvement in TD, while 7% showed more than 50% worsening of AIMS scores.Reference Caroff, Davis and Miller 59 The relationship to treatment is informative, as 5% to 67% of patients may have TD that is covert or masked by ongoing antipsychotic treatment and only becomes apparent after drug discontinuation.Reference Caroff, Ungvari and Cunningham Owens 7 Withdrawal dyskinesia is defined by a movement first observed after treatment cessation that subsides within 4-12 weeks after antipsychotic discontinuation

Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts

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10.1080/09168451.2018.1547104 Biosci