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Relationship between asymptomatic hypercholanaemia of pregnancy and progesterone metabolism

Although hydrolyzed FB1 (HFB1) is not toxic, the C2 amino group can be acylated by fatty acids in vivo to generate a ceramide synthase inhibitor that is 10-times more toxic than FB1 in mammalian HT-29 cells (Seiferlein et al., 2007)