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Together, these preclinical models consistently demonstrate that NAC exerts neuroprotective effects by counteracting mitochondrial dysfunction, restoring redox balance, suppressing inflammation, and preserving dopaminergic integrity

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Additionally, neurophysiological assessments, including nerve conduction studies, quantitative sensory testing, skin biopsy, corneal confocal microscopy, and SUDOSCAN, are valuable tools for detecting alterations in BIPN symptoms and assessing the effectiveness of treatments (Kandula et al., 2017