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Levinthal argued that there is no need to search this vast space since the energy landscape is funnel-like, rather than flat, and thus can guide sampling toward the biological conformational basin

Overall, optimal T3 levels depend on sufficient nutrient status, a well-functioning liver and gut, and balanced adrenal and stress hormone levels

Mechanistically, we elucidated that the improved anti-PC efficacy of co-delivery nanovesicles was attributed to the better ability to decrease the levels of cytidine deaminase (CDA), which can degrade GEM to its inactive metabolite by inducing the oxidative stress (HO-1) 35 , and the increased expression of apoptosis (cleaved caspase-3