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In addition, it significantly facilitates the healing of bone fracture in rats (15)

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The capsules used in this supplement are relatively large, which may make them difficult to swallow for some people

Future studies should use lower doses to determine the threshold concentration of B12 in the gut necessary to change the activities of the microbiota, particularly in the Lachnospiraceae populations and how these changes impact microbe-host interactions in the gut with a specific focus on IL-12p40 cytokine production along the GI tract

doi: 10.1016/j.cell.2012.03.042 11 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al