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doi:10.1371/journal.pone.0180280 Bhatti J, Nascimento B, Akhtar U, etal

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The influence of HO-1 on the TME immunoprofile was highlighted by Alaluf et al., who reported that myeloid-specific ablation of HO-1 induced global transcriptional and epigenetic alterations not limited to the conventional M1/M2 polarization state of TAMs, but rather leading to extensive dysregulation of the central molecular signature of the TME (45)

Colon sections were processed through the gut bundling technique, as previously described ( All samples were preserved at -80C until further utilization

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