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The pathophysiology of ICH involves both primary mechanical damage from hematoma expansion and secondary biochemical and biomechanical alterations that exacerbate neuronal injury (181)

Colony-stimulating factors (rhG-CSF, rhGM-CSF, rhIL-3, and BCGF) recruit myeloblastic and lymphoblastic leukemic cells and enhance the cytotoxic effects of cytosine-arabinoside

Genetically encoded FRET sensors to monitor intracellular Zn 2+ homeostasis

During septicemia, activated immune cells shift their metabolic profile from oxidative phosphorylation within the mitochondria to glycolysis within the cytoplasm through a process known as Warburg metabolism

To this end, many drugs have been repurposed, including tocilizumab, sarilumab, heparin, chloroquine, ivermectin, sarilumab, chromones ( Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation ( This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms ( NSAIDs, Paracetamol, and COVID-19 In March 2020, ibuprofen and NSAIDs were discouraged because of the alert by Micallef et al