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Chronic ethanol exposure not only induces hepatocyte death but also suppresses regenerative proliferation, thereby creating a pathological microenvironment conducive to ALD progression [43]

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In line with snRNA-seq data, protein levels of the LAM-marker MMP12 were significantly upregulated by IF in an adipocyte p53-dependent manner, whereas expression of the PVM marker ENDOB1 remained unchanged between groups (Fig