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Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption

FIGURE 1 3.2.2 CSD theory Trigeminal afferent activation sets off the pain pathway, which sends information to the TG, the TNC, and finally to the brainstem and cortical structures involved in pain processing, resulting in pain (Zhang et al., 2011)