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In previous reports, Asp60 hTrx1 has been mentioned as an important residue that quenches Trp31 hTrx1 (refs 17,25)

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Long-term oral studies of acetylcysteine alone in rats (12 months of treatment followed by 6 months of observation) at doses up to 1,000 mg/kg/day (5.2 times the human mucolytic dose) provided no evidence of oncogenic activity

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