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As expected, healthcare systems exhibit substantial cost savings from the use of biosimilars not only due to their reduced price, but also by the consequent fall in the originator anti-TNFs cost [175]

Research doesn't clearly favor one approach

The only thing I noticed is that she has been drinking the high end of normal amount of water for her ~1/2 cup per day and also peeing a bit more

Experts suggest that if a patients serum vitamin B12 level is between 150 to 399 pg/mL (111 to 294 pmol/L), the patients serum MMA levels should be checked to help confirm a diagnosis of vitamin B12 deficiency [7,9]

Nov 2023;75(11):2359-2368