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Similar observations have been reported following treatment of minimal residual disease-positive B-lineage acute lymphoblastic leukaemia with the bispecific T cell engager blinatumomab, where some patients showed an IL-6 response in the absence of detectable IFN- 50

Shaking the vial during reconstitution creates mechanical shear forces that denature 1525% of the peptide structure, converting it to inactive aggregates cleared rapidly without producing metabolic effects