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All these cell types appear to use an NAD(P)H oxidase similar to the classical leukocyte NADPH oxidase to produce these oxidants

10.1002/glia.23806 221 RutchikJ

Growing evidence suggests that targeting ferroptosis may offer benefits for CNS disorders, driving the development of effective inhibitors (24,95)

In the absence of Cur-AuNPs, no oxidation of TMB was observed, even in the presence of HO, indicating that the reaction is not spontaneous and confirming the necessity of a catalyst, similar to the action mechanism of horseradish peroxidase (HRP)