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Description

Among these two kinases, mTORC1 plays a key role in maintaining metabolic homeostasis, protein and lipid synthesis, glycolysis, mitochondrial biosynthesis, and lysosomal function by sensing various stimuli, such as amino acids, growth factors, and oxygen, thereby regulating activity of transcription factor and directly modulating translation processes

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Arg33, Ser44, Gly45, Glu50, Arg62, Glu65, Cys66, Glu87, Glu88, Glu91, Ala94, Gly95, Tyr96, Asn97, Pro167, His168, and Phe170 enhanced water bridge with Liproxstatin-1

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[DOI] [PubMed] [Google Scholar] 228.Ulvik A, Ebbing M, Hustad S, Midttun O, et al

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