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Scientists hypothesize that elevated homocysteine levels might have a negative effect on the brain via numerous mechanisms, including cerebrovascular ischemia leading to neuronal cell death, activation of tau kinases leading to tangle deposition, and inhibition of methylation reactions [82]

Data are presented as mean and standard error of the mean (SEM) or numbers

Initial investigations for hair loss should include a full blood count, serum ferritin, and thyroid function tests, as guided by NICE CKS on alopecia

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For example, if the initial benefits wane, the dosage or frequency of injections may need to be adjusted