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Nutr Cancer (2020) 72(7):120010

Sonowal R, Swimm A, Sahoo A, et al

Notably, long-term IGF-1 deficiency was considered the most critical biosignature associated with neurodegeneration and neuroinflammation in individuals with DS

Therefore, clinical testing in controlled populations is ultimately required to assess whether this preclinical efficacy is also observed in patients with CRC, both first-line in high-risk patients with high oxidative metabolic signalling (Fig