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TB-500 is under FDA advisory review in July 2026, and FDA staff documents recommend caution because human safety and effectiveness data are limited

Accessed 14 Aug

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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure