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6 , a028324 (2016)

De Yang, Chen, Q., Schmidt, A.P., Anderson, G.M., Wang, J.M., Wooters, J., et al., J

the effect is sustained by the biological process it initiates

To date, PARP inhibitors, including niraparib, rucaparib and olaparib have been approved by US-FDA to treat cancers, including prostate cancer, breast cancer and ovarian cancer, through disrupting DNA repair and replication pathways

When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established