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In conclusion, the intricate interplay between metabolic diseases and protein homeostasis underscores the pivotal role of proteostasis networks, including the UPS, autophagy, and the UPR, in the pathogenesis of conditions such as obesity, T2DM, and MASLD (Fig

This underscores the variability in experimental outcomes and the need for standardized methodologies as mentioned by several authors 27,52

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The whole blood used in our experiments was not neutrophil enriched, in contrast to the local accumulation of high amounts of neutrophils in osteomyelitis which are recruited to the site of infection

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