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After AGEs directly cross-link or indirectly bind to cell surface receptors, they activate MAPK signalling molecules, including p38, phosphatidylinositol 3-kinase (PI3K)/Akt, MAPK/ERK, and JIKs, and the combination of AGEs and RAGEs also increases ROS production

The market for nanocomposites is gradually growing over time because of innovation, research, and development, and shifting toward eco-friendly products

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Figure 1 Patients with GSSD, which is classified as mild, moderate, or severe based on clinical symptoms, usually show disease onset symptoms during the neonatal period ( 2

Introduction Chemical inducers of proximity (CIPs) include bifunctional small molecules and molecular glues that induce proximity between two targets, often leading to neomorphic effects that can be leveraged to re-wire biological circuits, which is difficult to achieve with other pharmacological approaches 1,4