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Statements Acknowledgments This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) AN746/3-1 and AN746/4-1 within the DFG priority program SPP1710, by the DFG Research Training Group GRK1947, project [C1] and by an ERC Consolidator Grant (GA 615585) MYCOTHIOLOME to H.A

To this end, the development of new therapies, ideally targeting synovitis and inflammatory-related bone erosion in joints, as well as regulating those inflammation-independent factors that can also interfere with bone homeostasis in RA, such as the general RANKL signaling pathway, would be promising for remodeling bone homeostasis in RA

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

-Glucuronidase, a representative microbial enzyme secreted by gut bacteria, catalyzes the hydrolysis of glucuronide conjugates and xenobiotic detoxification processes