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Further studies showed that CDC appears to be a more prominent effector mechanism for daratumumab [22, 28], with evidence suggesting that isatuximab induces CDC only in the presence of high CD38 receptor density [24, 32]

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Other side effects reported ranged from lipohypertrophy at injection site, papilloedema (related to cranial hypertension), and facial nerve paralysis [276, 285], however symptoms did not prevail after treatment pause and restarting with lower doses [268]

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