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DDR of inter-strand crosslinks (ICLs) Repairing interstrand crosslinks (ICLs) involves another DDR pathway, such as NER and HR

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doi: 10.1002/acr.24596

Simultaneously, 5-LOX is recruited to the nuclear envelope, where it binds to the 5-LOX-activating protein (FLAP) and acts on AA to generate leukotriene A4 (LTA4)