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DCA can activate HIF-2 signaling, increase DMT1 expression, elevate epithelial Fe + accumulation, and trigger ferroptosis

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Treatment options are targeted to the underlying disease that led to the B12 deficiency, which may include infections, pancreatic diseases, digestive disorders, and others

Here, we show that the eukaryotic OGA pHAT domain forms catalytically incompetent, symmetric homodimers, projecting a partially conserved putative peptide-binding site