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J Ethnopharmacol 276:113991 Zhu X, Sun M, Guo H, Lu G, Gu J, Zhang L, Shi L, Gao J, Zhang D, Wang W (2022) Verbascoside protects from LPS-induced septic cardiomyopathy via alleviating cardiac inflammation, oxidative stress and regulating mitochondrial dynamics

The fact that this MIC far exceeds the clinical breakpoint by several-fold to tens of folds strongly suggests that the bacterium likely produces drug-inactivating enzymes, such as aminoglycoside-modifying enzymes, which efficiently destroy antibiotic molecules, leading to high-level resistance