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In a small pilot study of elderly patients with a mild cognitive deficit, the ability to remember previously learned items improved, and depression decreased with melatonin [105]

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In another study of rats, following a 50 mg/kg dose of luteolin orally or intravenously, luteolin bioavailability was shown to be low, at 4.10%, with a rapid absorption and metabolism rate, large distribution, and high clearance, suggested to be owed to an enterohepatic recirculation [174]