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Following absorption from the Gastrointestinal tract, paracetamol is metabolised predominantly in the liver where it is conjugated into inactive glucuronide and sulphate conjugates, which are excreted in urine, and toxic N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione

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At the molecular level, it modulates the expression of over 4,000 human genes, roughly 6% of the genome, according to a 2012 Broad Institute Connectivity Map analysis published by Pickart, Campbell, and colleagues

Presently, the structural design of MOFs has piqued the interest of researchers for detection of GSH owing to its remarkable and adaptable qualities such as high sensitivity, excellent selectivity in clinical samples, food components, agriculture goods, nutritional supplements, and so on