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Stroke, a major risk factor for fragility fractures, increases the risk of post-stroke disability and mortality, with stroke survivors experiencing a seven-fold higher incidence of fragility fractures (49)

Intracellular accumulation of reduced iron (Fe 2+ ) and lipid peroxides (PLOOH), which are generated from polyunsaturated fatty acids (PUFA) through Acyl-CoA synthetase long chain family member 4 (ACSL4)-mediated catalysis, triggers the Fenton reaction 15

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