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Description

10.1152/ajpcell.00643.2008 Am

10.1002/brb3.362 15 GhaffarianR.HerreroE

Other pharmacological options include catechol-O-methyltransferase (COMT) inhibitors like entacapone and opicapone, which extend the half-life of levodopa, do not cross the BBB at all and primarily affect peripheral metabolism, providing no direct action in the brain 59