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Christen K (2001) The arsenic threat worsens

Here, we found that REST was upregulated in AKI patients, mice, and RTECs, which was positively associated with the degree of kidney injury, while renal tubulespecific knockout of Rest significantly alleviated AKI and its progression to chronic kidney disease (CKD)

PMID 2490426

When levels are low, cells are left more vulnerable to oxidative damage accelerating the aging process and increasing the risk of various chronic diseases