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In addition, the GPx defends against oxidants that cause neuronal and protein damage, which reduce H 2 O 2 and lipid peroxide to water and alcohol, respectively

DPP-IV, an important target for antidiabetic functional food design

Modulation of thioredoxins and thioredoxin interacting protein (TXNIP) showed that TRX1 overexpression or knockdown of TXNIP attenuated NLRP3 inflammasome activation, reinforcing the role of inflammasome activation by oxidants and subsequent generation of proteins, IL-1B and HMGB1, linked to mesothelioma development (66, 67)

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Diseases associated with premature aging (Werner's Syndrome, another link to Werner's Syndrome, Progeria) show very high levels of oxidized proteins at an early age